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University of Central Lancashire, Preston, Lancashire, UK Contributed by Jane Kennet, BSc, and Natalie Hardaker, BSc Hons , contributed to conception and design; acquisition and analysis and interpretation of the data; and drafting, critical revision, and final approval of the article. Sarah Hobbs, PhD, and James Selfe, PhD, contributed to the conception and design; acquisition of data; and drafting, critical revision, and final approval of the article. Address e-mail to ku. This article has been cited by other articles in PMC. Abstract Context: Cryotherapy is the application of cold as a treatment.

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Globally, it infects over 50 million people and causes 28, human deaths every year, making it the most important food-borne zoonosis. Adult T. Ingestion of the eggs via contaminated food or water leads to infection with the larval stage of the parasite — usually in pigs porcine cysticercosis, PCC but also in humans human cysticercosis, HCC. NCC can cause severe progressive headache, blindness and stroke, and is the leading cause of epilepsy in the developing world.

While effective tools for control of T. No similar integrated studies have yet been conducted in sub-Saharan Africa, where levels of T. It aims to evaluate the effectiveness, cost-effectiveness and local acceptability of a short-term, integrated human- and pig-based T. Sampling of pigs and humans was conducted at the beginning, middle and end of the intervention period to evaluate the impact of the interventions on disease occurrence.

These results showed that the integrated interventions significantly decreased T. Three additional objectives were investigated in this doctoral study. Baseline questionnaires collected preliminary costing data relating to pig-keeping in the villages, and investigated human health conditions commonly associated with NCC seizures, chronic headache, vision problems.

Pigs infected with PCC were mostly unable to be sold, causing substantial economic losses for subsistence farmers.

Focus group discussions and questionnaires conducted in the study villages collected qualitative data about the local acceptability and perceptions of the piloted interventions.

Feedback indicated that the interventions were generally well accepted and valued by the communities, although there were reportedly some concerns that the vaccinations being given to pigs were causing pig deaths.

Behavioral changes had reportedly been implemented in the villages to reduce parasite transmission e. Finally, educational workshops conducted in three primary schools used a computer-based T. The results of this thesis provide important proof of concept that an integrated human- and pig-based intervention strategy can potentially eliminate T.

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